For centuries, mankind has been the dominant species. We've domesticated animals, locked them up, killed them for sport. But what if, all across the globe, the animals decided "no more"? What if they finally decided to fight back? Violent animal attacks upon humans are occurring all over the world. Jackson Oz, an American zoologist who offers safaris in Africa, begins to notice the animals' strange behavior and takes it upon himself to solve the reason why before these attacks become more coordinated and ferocious.